Patrick Henry, who's father was from Aberdeen (last I checked in  
Scotland), around 1732 married Sarah Winston Syme, a wealthy widow  
from a prominent Hanover County family of English ancestry. In 1754  
Patrick Henry married Sarah Shelton, from the name also of English  
stock.

That took all of 2 minutes to find. I'm sure there are lots of other  
Scots and Scots-Irish that married people of English descent. While  
religion might have been a bigger factor among the plantation families  
of the coastal plain, upcountry you married who was available and by  
the mid 1700s not everyone was an Anglican anyway.

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